PROJECTS
In vivo observation of biological molecules using polarisation dependant second-harmonic generation microscopy.
Year: 2009
Funded by: Spanish Ministry of Economy and Competitiveness, TEC2009-09698.
Compact ultrafast laser sources based on novel quantum dot structures (FAST-DOT).
Year: 2008
Funded by: EU. 7th framework programme. Collaborative projects. Large-scale integrating project (IP); Call: FP7-ICT-2007-2.
Link: FAST-DOT
Spatio-temporal Engineering of Light. Ultimate Multiphoton Microscopy (STELUM).
Year: 2008
Funded by: 7th framework programme. Marie Curie IAPP. Call: FP7-PEOPLE-2007-3-1-IAPP.
Link: STELUM
Terapias neuro-reparadoras (TNR).
Year: 2007
Funded by: Centre d’Innovació i desenvolupament Empresarial (CIDEM)
Pulse-shaping in multiphoton microscopy. A new dimension for imaging living-cells.
Year: 2006
Funded by: Spanish Ministry of Economy and Competitiveness, TEC2006-12654.
Raman – based applications for clinical diagnostics (Raman4clinics)
Year: 2014
Funded by: EU: European cooperation in Science and Technology, BMBS COST Action BM1401.
Elucidating cellular heterogeneity among cancer stem cells by Raman Spectroscopy
Year: 2014
Funded by: National Cancer Institute. National Institutes of Health (NIH, USA).
Bioimagen microscópica con láseres de luz blanca (Imaginewhite).
Year: 2014
Funded by: Spanish Ministry of Economy and Competitiveness Retos Colaboración 2014 (RTC-2014-2060-1).
Link: Imaginewhite
Development of advanced Laser Imaging Techniques for the anterior and posterior Eye (LITE).
Year: 2014
Funded by: Line Line A. BioPhotonics Plus. Transnational Call 2012/2013: Translation into practical applications.
Link: LITE
Compact STED CW sources emitting in the yellow range.
Year: 2011
Funded by: EU, FP7-ICT-2009.3.7: Photonics: Network for EXchange and PRototype Evaluation of photonicS componentS and Optical systems (NEXPRESSO).
Estudio de las alteraciones de funciones celulares ligadas a cambios en Ubicuitilación y SUMOlación inducidos por oncogenes virales (Ub/SUMO).
Year: 2019
Funded by: CONACYT (MX) SRE 2016-1.
Preservation of microorganisms by understanding the protective mechanisms of oligosaccharides (PREMIUM).
Year: 2018
Funded by: Marie Skłodowska-Curie Research and Innovation Staff Exchange (H2020-MSCA-RISE-2017)
Module for Aberration Correction and Fast Volumetric Imaging in a Light Sheet Fluorescence Microscope (MAFIn).
Engineered models of intestinal epithelial tissue: assessing in vivo-like functional properties (ENGUT).
Towards the implementation of a multi-electrode array for retinal prosthesis II (THEIA II).
Multi-modal, multi-scale retinal imaging (Merlin 780989).
LOW Coherent White Lasers Ready for MICroscopy II (P2017 -10).
Towards the implementation of a multi-electrode array for retinal prosthesis (THEIA).
Visualización volumétrica rápida de las dinámicas de calcio para el estudio de comunicación neuronal en 3D (3D-VIDy-neuron).
Year: 2016
Funded by: Spanish Ministry of Economy and Competitiveness (FIS2016-80455-R)
Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine (MESOBRAIN).
Year: 2016
Funded by: Future and Emerging Technologies (H2020-FET OPEN-2014-2015-RIA)
Link: MESOBRAIN
Training European Experts in Multilevel Bioimaging, Analysis and Modelling of Vertebrate Development and Disease (ImageInLife).
Year: 2016
Funded by: Marie Skłodowska-Curie Innovative Training Networks (H2020-MSCA-ITN-2016)
Link: ImageInLife
Molecular imaging of the retina in patients with Multiple Sclerosis by Raman Spectroscopy (20142030).
Year: 2015
Funded by: TV3 Foundation’s La Marató
Dissecting protein trafficking in retinal neurodegeneration by super-resolution imaging on animal models and human iPSCs (20141730).
Year: 2015
Funded by: TV3 Foundation’s La Marató
LOW Coherent White Lasers Ready for MICroscopy (P2014-60).
Comprehensive molecular and microspectroscopic profiling of breast carcinomas and their resistance to neadjuvant treatment
Years: 2020-2024
Funded by: TV3 Foundation’s La Marató
Our role:
- To demonstrate the possible usefulness of Raman microspectroscopy (RMS) for the diagnosis and molecular typing of breast cancer as well as its possible immediate use on fresh needle biopsy samples prior to neoadjuvant therapy.
Link: La Marató 2018 – Cancer
Training network for Next generation cellular Screening (NEXT SCREEN)
Starting year: 2023
Funded by: MARIE SKŁODOWSKA-CURIE ACTIONS, UE
Reference: HORIZON-MSCA-2022-DN-01-01
Our role:
- Develop a new fluidic imaging system, using high resolution long working distance microscope objective lenses, integrated with non-diffractive beams for illumination. This will allow capturing high-resolution 3D images on a large field of view, recording hundreds-cells/s.
- Develop an illuminator based on an optical lantern (patented at ICFO) to generate incoherent light source compatible with light sheet illumination of elastic scattering as a source of contrast mechanism (avoiding shadowing effects typical of coherent illumination)
Link: NEXTSCREEN
Data-intensive bioimage analysis for advancing retinal degenerative diseases therapies (Digital Retina).
Starting year: 2022
Funding: MCIN /AEI /10.13039/501100011033 / FEDER, UE
Reference: PID2021-122807OB-C31
Our role:
- ADVANCED IMAGING FOR VISUALIZING THE FUNCTIONAL CIRCUITRY OF RETINAS. To visualize the complex spatio-temporal electrical patterns propagated in healthy, atrofic and transplanted retinas, we will build a high-resolution fast volumetric imaging system. The microscope will be adapted to contain and properly preserve the retina state.
Link: DigitalRetina
SLN intelligent datasets management.
Year: 2021
Funded by: Red Española de SuperComputación
Adaptive Retinal Implant Technology for Vision Restoration (iVISION).
Evaluación in vivo de una matriz de electrodos de grafeno para prótesis retinianas (GraphRetina).
Year: 2018
Funded by: GraphCAT
Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy (Amplitude 871277).
Year: 2018
Funded by: Research and Innovation Action (H2020-ICT-2018/H2020-ICT-2019-2)
Link: AMPLITUDE
PUBLICATIONS
2024
- TANGO1 inhibitors reduce collagen secretion and limit tissue scarring. Raote, I., Rosendahl, A., Häkkinen, H., Vibe, C., Küçükaylak, I., Sawant, M., Keufgens, L., Frommelt, P., Halwas, K., Broadbent, K., Cunquero, M., Castro, G., Villemeur, M., Nüchel, J., Bornikoel, A., Dam, B., Zirmire, R. K., Kiran, R., Carolis, C., Andilla, J., Loza-Alvarez, P., Ruprecht, V., Jamora, C., Campelo, F., Krüger, M., Hammerschmidt, M., Eckes, B., Neundorf, I., Krieg, T., & Malhotra, V. (2024). Nature.
- Dynamics of macrophage polarization support Salmonella persistence in a whole living organism. Leiba, J., Sipka, T., Begon-Pescia, C., Bernardello, M., Tairi, S., Bossi, L., Gonzalez, A., Mialhe, X., Gualda, E. J., Loza-Álvarez, P., Blanc‐Potard, A., Lutfalla, G., & Nguyen-Chi, M. (2024). eLife, 13.
2023
- Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo. Sortino, R., Cunquero, M., Castro-Olvera, G., Gelabert, R., Moreno, M., Riefolo, F., Matera, C., Fernàndez‐Castillo, N., Agnetta, L., Decker, M., Lluch, J. M., Hernando, J., Loza-Álvarez, P., & Gorostiza, P. (2023). Angewandte Chemie, 62(51).
- Volumetric Temperature Mapping Using Light-Sheet Microscopy and Upconversion Fluorescence from Micro- and Nano-Rare Earth Composites. Barron-Ortiz, D., Cadena-Nava, R. D., Pérez-Parets, E., Licea-Rodríguez, J., Gualda, E. J., Hernández‐Cordero, J., Loza-Álvarez, P., & Rocha‐Mendoza, I. (2023). Micromachines, 14(11), 2097.
- Calcium Imaging In Electrically Stimulated Flat-Mounted Retinas. Cunquero, M., Marsal, M., Castro-Olvera, G., Walston, S. T., Duvan, F. T., Macias-Montero, J. G., Puigdengoles, C., Chmeissani, M., Garrido, J. A., & Loza-Álvarez, P. (2023). Journal of Visualized Experiments, 198.
- Study of the photobleaching phenomenon to optimize acquisition of 3D and 4D fluorescence images. A special scenario for trilinear and quadrilinear models. Gómez-Sánchez, A., Alvarez, I. A., Loza-Álvarez, P., Ruckebusch, C., & De Juan, A. (2023). Microchemical Journal, 191, 108899.
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Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity. Planas-Serra, L., Launay, N., Goicoechea, L., Heron, B., Jou, C., Juliá-Palacios, N., Ruiz, M., Fourcade, S., Casasnovas, C., de La Torre, C., Gelot, A., Marsal, M., Loza-Alvarez, P., García-Cazorla, À., Fatemi, A., Ferrer, I., Portero-Otin, M., Area-Gómez, E., & Pujol, A. (2023). The Journal of Clinical Investigation, 133(10).
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Crop rotation with Meloidogyne-resistant germplasm is useful to manage and revert the (a)virulent populations of Mi1.2 gene and reduce yield losses. Fullana, A. M., Expósito, A., Escudero, N., Cunquero, M., Loza-Alvarez, P., Giné, A., & Sorribas, F. J. (2023). Frontiers in Plant Science, 14(March), 1–13.
- Infrared laser effects on cell projection depend on irradiation intermittence and cell activity. Medina-Villalobos, N., Ávila, R., Marsal, M., Andilla, J., Loza-Alvarez, P., Ramírez, M. M. O., & Tamariz, E. (2023). Cells, 12(4), 540.
2022
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Modeling Biochemical Gradients In Vitro to Control Cell Compartmentalization in a Microengineered 3D Model of the Intestinal Epithelium. Altay, G., Abad‐Lázaro, A., Gualda, E. J., Folch, J., Insa, C., Tosi, S., Hernando‐Momblona, X., Batlle, E., Loza‐Álvarez, P., Fernández‐Majada, V., & Martinez, E. (2022). Advanced Healthcare Materials, 11(22), 2201172.
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Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy. Morales-Curiel, L. F., Gonzalez, A. C., Castro-Olvera, G., Lin, L.-C., El-Quessny, M., Porta-de-la-Riva, M., Severino, J., Morera, L. B., Venturini, V., Ruprecht, V., Ramallo, D., Loza-Alvarez, P., & Krieg, M. (2022). Communications Biology, 5(1), 1330.
- Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex. Joubert B, Petit‐Pedrol M, Planagumà J, Mannara F, Radosevic M, Marsal M, Maudes E, García‐Serra A, Aguilar E, Andrés‐Bilbé A, Gasull X, Loza‐Alvarez P, Sabater L, Rosenfeld MR and Dalmau J. Ann Neurol (2022)
- Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma. Quinet G, Xolalpa W, Reyes-Garau D, Profitós-Pelejà N, Azkargorta M, Ceccato L, Gonzalez-Santamarta M, Marsal M, Andilla J, Aillet F, Bosch F, Elortza F, Loza-Alvarez P, Sola B, Coux O, Matthiesen R, Roué G and Rodriguez, MS. Cancers (2022)
- Novel Non-Invasive Quantification and Imaging of Eumelanin and DHICA Subunit in Skin Lesions by Raman Spectroscopy and MCR Algorithm: Improving Dysplastic Nevi Diagnosis. Ruiz JJ, Marro M, Galván I, Bernabeu-Wittel J, Conejo-Mir J, Zulueta-Dorado T, Guisado-Gil AB and Loza-Álvarez P. Cancers (2022)
- Multi-modal and multi-scale clinical retinal imaging system with pupil and retinal tracking. Shirazi MF, Andilla J, Lefaudeux N, Valdes C, Schwarzhans F, Durand M, Ntatsis K, De Jesus DA, Sanchez Brea L, Gocho K, Gautier J, Eckmann-Hansen C, Torm MEW, Amini A, Klein S, Van Walsum T, Grieve K, Paques M, Larsen M, Loza-Alvarez P, Levecq X, Chateau N and Pircher M. Sci Rep (2022)
- Focus variation due to near infrared laser in a confocal microscope. Matrecitos‐Avila M, Avila R, Pimentel‐Domínguez R, Cuevas S, Tamariz E, Loza‐Alvarez P. Microsc Res Tech (2022)
- Few-cycle all-fiber supercontinuum laser for ultrabroadband multimodal nonlinear microscopy. Almagro-Ruiz A, Torres-Peiró S, Muñoz-Marco H, Cunquero M, Castro-Olvera G, Dauliat R, Jamier R, Shulika OV, Romero R, Guerreiro PT, Miranda M, Crespo H, Roy P, Loza-Álvarez P and Pérez-Millán P. Opt Express (2022)
- Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis. Cunquero M, Aguilar E, Loza-Alvarez P, Planagumà J. J Vis Exp. (2022)
- The Capillary Morphogenesis Gene 2 Triggers the Intracellular Hallmarks of Collagen VI-Related Muscular Dystrophy. Castroflorio E, Pérez Berná AJ, López-Márquez A, Badosa C, Loza-Alvarez P, Roldán M and Jiménez-Mallebrera, C. Int J Mol Sci (2022)
- Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. Antón-Galindo E, Dalla Vecchia E, Orlandi JG, Castro G, Gualda EJ, Young AMJ, Aguado F, Loza-Alvarez P, Cormand B, Norton WHJ and Fernàndez-Castillo N. Mol Psychiatry. (2022)
- Modular multimodal platform for classical and high throughput light sheet microscopy. Bernardello M, Gualda EJ and Loza-Alvarez P. (2022) Scientific Reports.
- Multiple asters organize the yolk microtubule network during dclk2-GFP zebrafish epiboly. Marsal M, Bernardello M, Gualda EJ and Loza-Alvarez P. Scientific Reports (2022)
2021
- Autofluorescence of stingray skeletal cartilage: hyperspectral imaging as a tool for histological characterization. Chaumel, J., Marsal, M., Gómez-Sánchez, A., Blumer, M., Gualda, E. J., de Juan, A., Loza-Alvarez, P., Dean, M. N. (2021). Discover Materials, 1(1).
- Preprint: Fusion of Hyperspectral Images . Looking at the structure of vegetal tissues : a case study. Gómez-Sánchez, A., Marro, M., Marsal, M., Zacchetti, S., Rocha de Oliveira, R., Loza-Alvarez, P., & De Juan, A. (2021). Research Square, 0–16.
- Linear unmixing protocol for hyperspectral image fusion analysis applied to a case study of vegetal tissues. Gómez-Sánchez, A., Marro, M., Marsal, M., Zacchetti, S., Rocha de Oliveira, R., Loza-Alvarez, P., & de Juan, A. (2021).Scientific Reports, 11(1), 1–14.
- Unravelling the encapsulation of dna and other biomolecules in hap microcalcifications of human breast cancer tissues by raman imaging. Marro, M., Rodríguez-Rivero, A. M., Araujo-Andrade, C., Fernández-Figueras, M. T., Pérez-Roca, L., Castellà, E., … Loza-Alvarez, P. (2021). Cancers, 13(11).
- Fructose derived oligosaccharides prevent lipid membrane destabilization and DNA conformational alterations during vacuum-drying of Lactobacillus delbrueckii subsp. bulgaricus. Romano, N., Marro, M., Marsal, M., Loza-Álvarez, P., & Gomez-Zavaglia, A. (2021). Food Research International, 143(February).
- Light-sheet fluorescence microscopy for the in vivo study of microtubule dynamics in the zebrafish embryo. Bernardello, M., Marsal, M., Gualda, E. J., & Loza-Alvarez, P. (2021). Biomedical Optics Express, 12(10), 6237.
- Analysis of intracellular protein dynamics in living zebrafish embryos using light-sheet fluorescence single-molecule microscopy. Bernardello, M., Gora, R. J., Van Hage, P., Castro-Olvera, G., Gualda, E. J., Schaaf, M. J. M., & Loza-Alvarez, P. (2021). Biomedical Optics Express, 12(10), 6205.
2020
- Preprint: The microtubule organization in the zebrafish yolk adapts to transgene-mediated phenotypic variations. M. Marsal, M. Bernardello, E. J. Gualda and P. Loza-Alvarez. BioRxiv Preprint.
- A computational diffusion model to study antibody transport within reconstructed tumor microenvironments. Cartaxo, A. L., Almeida, J., Gualda, E. J., Marsal, M., Loza-Alvarez, P., Brito, C., and Isidro, I. A. (2020). BMC Bioinformatics, 21(1), 1–19.
- The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior. Venturini, V., Pezzano, F., Castro, F. C., Häkkinen, H. M., Jiménez-Delgado, S., Colomer-Rosell, M., Marro M., Tolosa-Ramon, Q., Paz-López, S., Valverde, M.A., Weghuber, J., Loza-Alvarez, P., Krieg, M., Wieser, S. and Ruprecht, V. (2020). Science, 370(6514).
- A novel culture method that sustains ERα signaling in human breast cancer tissue microstructures. Cartaxo, A. L., Estrada, M. F., Domenici, G., Roque, R., Silva, F., Gualda, E. J., Loza-Alvarez P., Sflomos G., Brisken C., Alves C.M., André S. and Brito, C. (2020). Journal of Experimental and Clinical Cancer Research, 39(1), 1–14.
- Comparability of Raman Spectroscopic Configurations: A Large Scale Cross-Laboratory Study. Guo, S., Beleites, C., Neugebauer, U., Abalde-Cela, S., Afseth, N. K., Alsamad, F., … Araujo-Andrade, …, C. Loza-Alvarez P., … Marro M., …and Bocklitz, T. (2020). Analytical Chemistry, 92(24), 15745–15756.
- Response to Hypoxic Preconditioning of Glial Cells from the Roof of the Fourth Ventricle. Becerra-González, M., Varman Durairaj, R., Ostos Valverde, A., Gualda, E. J., Loza-Alvarez, P., Portillo Martínez, W., Gómez-González G.B., Buff A., Martínez-Torres, A. (2020). Neuroscience, 439, 211–229.
- Tomato and Melon Meloidogyne Resistant Rootstocks Improve Crop Yield but Melon Fruit Quality Is Influenced by the Cropping Season. A. Expósito, I. Achaerandio, A. Giné, N. Escudero, A.M. Fullana, M. Cunquero, P. Loza-Álvarez and F.J. Sorribas. (2020). Frontiers in Plant Science, 11(November).
- Spontaneous functional recovery after focal damage in neuronal cultures S. Teller, E. Estévez-Priego, C. Granell, D. Tornero, J. Andilla, O. E. Olarte, P. Loza-Alvarez, A. Arenas, J. Soriano. eNeuro. 7, 1-13 (2020)
- Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov. Lab on a Chip. 20, 1792-1806 (2020)
- 3D and 4D image fusion: coping with differences in spectroscopic modes among hyperspectral images Anal. Chem. 92, 14 (2020)
- Engineering polar oxynitrides: hexagonal perovskite BaWON2 Angew. Chem. [Online DOI: 10.1002/ange.202006519] (2020)
- Bacillus firmus strain I-1582, a nematode antagonist by itself and through the plant Front. Plant Sci. 11, 796 (2020)
- Parallel array with axially coded light-sheet microscope Light-Sci. Appl. 9, 65 (2020)
- Modulation-enhanced localization microscopy (meLM) J. Phys. Photonics [Online DOI: 10.1088/2515-7647/ab9eac] (2020)
- The interaction of RecA with both CheA and CheW is required for chemotaxis. . Front. Microbiol. 11, 583. (2020)
- Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions A. Plana-Bonamaisó, S. López-Begines, D. Fernández-Justel, A. Junza, A. Soler-Tapia, J. Andilla, P. Loza-Álvarez, J.L. Rosa, E. Miralles. eLife. 9, e56418 (2020)
- Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity eLife. 9, e55111 (2020)
- A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs Sci. Adv. 6, eaaz1588 (2020)
- GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress A. Plana-Bonamaisó, S. López-Begines, J. Andilla, M. J. Fidalgo, P. Loza-Álvarez, J. M. Estanyol. P. de la Villa, A. Méndez. Cell Death Dis. 11, 62 (2020)
2019
- Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility Sci. Rep. 9, 10492 (2019)
- SIMPLE: Structured illumination based point localization estimator with enhanced precision Opt. Express. 27, 24578 (2019)
- GRP94 is involved in the Lipid Phenotype of Brain Metastatic Cells N. Santana-Codina, A. Marcé-Grau, L. Muixi, C. Nieva, M. Marro, D. Sebastián, J. P. Muñoz, A. Zorzano, A. Sierra. Int. J. Mol. Sci. 20(16), 3883 (2019)
- Neuronal stretch reception – Making sense of the mechanosense
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Identifying crossing collagen fibers in human corneal tissues using pSHG images M. Alizadeh, D. Merino, G. Lombardo, M. Lombardo, R. Mencucci, M. Ghotbi, P. Loza-Alvarez. Biomed. Opt. Express. 10, 3875-3888 (2019)
- Enhanced Light Sheet Elastic Scattering Microscopy by Using a Supercontinuum Laser D. Di Battista, D. Merino, G. Zacharakis, P. Loza-Alvarez, O.E. Olarte. Methods Protoc. 2, 57 (2019)
- Comparison of Different Polarization Sensitive Second Harmonic Generation Imaging Techniques M. Alizadeh, M. Ghotbi, P. Loza-Alvarez, D. Merino. Methods Protoc. 2, 49 (2019)
- Large-Area Biomolecule Nanopatterns on Diblock Copolymer Surfaces for Cell Adhesion Studies V. Hortigüela, E. Larrañaga, A. Lagunas, G.A. Acosta, F. Albericio, J. Andilla, P. Loza-Alvarez, E. Martínez. Nanomaterials (Basel). 9;9(4):579. (2019)
- Nanoscale structure of amyloid-β plaques in Alzheimer’s disease M. Querol-Vilaseca, M. Colom-Cadena, J. Pegueroles, R. Nuñez-Llaves, J. Luque-Cabecerans, L. Muñoz-Llahuna, J. Andilla, O. Belbin, T.L. Spires-Jones, E. Gelpi, J. Clarimon, P. Loza-Alvarez, J. Fortea, A. Lleó. Sci Rep. 26;9(1):5181 (2019)
- Assessment of tissue-specific multifactor effects in environmental –omics studies of heterogeneous biological samples: Combining hyperspectral image information and chemometrics Talanta. 194, 390-398 (2019)
2018
- Raman spectroscopy quantification of eumelanin subunits in natural unaltered pigments I. Galván, C. Aurajo-Andrade, M. Marro, P. Loza-Álvarez, K. Wakamatsu. Pigment Cell Melanoma Res. 31, 673-682 (2018)
- Unravelling the metabolic progression of breast cancer cells to bone metastasis by coupling Raman spectroscopy and a novel use of Mcr-Als algorithm Marro, C. Nieva, A. de Juan, A. Sierra. Anal. Chem. 90, 5594-5602 (2018)
- Combining hyperspectral imaging and chemometrics to assess and interpret the effects of environmental stressors on zebrafish eye images at tissue level Olmos, M. Marro, P. Loza-Alvarez, D. Raldúa, E. Prats, F. Padrós, B. Piña, R. Tauler, A. de JuanJ. Biophoton. 11, e201870133 (2018) Cover page
- 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment P. Rebelo, C. Pinto, T. R. Martins, N. Harrer, M. F. Estrada, P. Loza-Alvarez, J. Cabeçadas, P. M. Alves, E. J. Gualda, W. Sommergruber, C. Brito. Biomaterials 163, 185-197 (2018)
- Transcriptome analysis in tissue sectors with contrasting crocins accumulation provides novel insights into apocarotenoid biosynthesis and regulation during chromoplast biogenesis Ahrazem, J. Argandoña, A. Fiore, C. Aguado, R. Luján, A. Rubio-Moraga, M. Marro, C. Araujo-Andrade, P. Loza-Alvarez, G. Diretto, L. Gómez-Gómez. Sci. Rep. 8, 2843 (2018)
- Light-sheet microscopy: a tutorial E. Olarte, J. Andilla, E. J. Gualda, P. Loza-Alvarez. Adv. Opt. Photon. 10, 111-179 (2018)
- Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening D’Andrea, M. Simon-Moya, B. Llorente, E. Llamas, M. Marro, P. Loza-Alvarez, L. Li, M. Rodriguez-Concepcion. Journal of Experimental Botany. 69, 1557–1568 (2018)
2017
- Synaptic phosphorylated alpha-synuclein in dementia with Lewy bodies Colom-Cadena, J. Pegueroles, A. G. Herrmann, C. M. Henstridge, L. Muñoz, M. Querol-Vilaseca, C. S. Martín-Paniello, J. Luque-Cabecerans, J. Clarimon, O. Belbin, R. Núñez-Llaves, R. Blesa, C. Smith, C. McKenzie, M. P. Frosch, A. Roe, J. Fortea, J. Andilla, P. Loza-Alvarez, E. Gelpi, B. T. Hyman, T. L. Spires-Jones, A. Lleó. Brain. 140, 3204-3214 (2017)
- Sub-diffraction discrimination with polarization-resolved two-photon excited fluorescence microscopy Artigas, D. Merino, C. Polzer, P. Loza-Alvarez. Optica. 4, 911-918 (2017)
- Relevant aspects of unmixing/resolution analysis for the interpretation of biological vibrational hyperspectral images Olmos, L. Benítez, M. Marro, P. Loza-Alvarez, B. Piña, R. Tauler, A. de Juan. Trends Anal. Chem. 94, 130-140 (2017)
- Three-dimensional imaging flow cytometry through light-sheet fluorescence microscopys J. Gualda, H. Pereira, G. G. Martins, R. Gardner, N. Moreno. Cytometry Part A. 91A, 144-151 (2017)
- Imaging tissue-mimic with light sheet microscopy: A comparative guideline Andilla, R. Jorand, O. E. Olarte, A. C. Dufour, M. Cazales, Y. L. E. Montagner, R. Ceolato, N. Riviere, J-C. Olivo-Marin, P. Loza-Alvarez, C. Lorenzo. Sci. Rep. 7, 44939 (2017)
- High-resolution morphological approach to analyse elastic laminae Injuries of the ascending aorta in a murine model of Marfan syndrome López-Guimet, J. Andilla, P. Loza-Alvarez, G. Egea. Sci. Rep. 7, 1505 (2017)
- STED imaging performance estimation by means of Fourier transform analysis Merino, A. Mallabiabarrena, J. Andilla, D. Artigas, T. Zimmermann, P. Loza-Alvarez. Biomed. Opt. Express. 8, 2472-2482 (2017)
- Multiphoton imaging with blue-diode-pumped SESAM-modelocked Ti:sapphire oscillator generating 5 nJ 82 fs pulses Andreas Rohrbacher, Omar E. Olarte, Vesna Villamaina, Pablo Loza-Alvarez, and Bojan Resan. Opt. Express. 25, 10677-10684 (2017)
2016
- Polarized cortical tension drives zebrafish epiboly movements Hernández-Vega, M. Marsal, P.-A. Pouille, S. Tosi, J. Colombelli, T. Luque, D. Navajas, I. Pagonabarraga, E. Martín-Blanco. Embo J. e201694264 (2016)
- Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy Stremersch, M. Marro, B.-E. Pinchasik, P. Baatsen, A. Hendrix, S. C. De Smedt, P. Loza-Alvarez, A. G. Skirtach, K. Raemdonck, K. Braeckmans. Small. 12, 3292-3301 (2016)
- Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene Stefaniuk, E. J. Gualda, M. Pawlowska, D. Legutko, P. Matryba, P. Koza, W. Konopka, D. Owczarek, M. Wawrzyniak, P. Loza-Alvarez, L. Kaczmarek. Sci. Rep. 6, 28209 (2016)
- Adaptive optics scanning laser ophthalmoscope imaging: technology update Merino, P. Loza-Alvarez. Clin. Ophthalmol. 10, 743-755 (2016)
- Two photon versus one photon fluorescence excitation in whispering gallery mode microresonators Pastells, M.-P. Marco, D. Merino, P. Loza-Alvarez, L. Pasquardini, L. Lunellid, C. Pederzolli, N. Daldosso, D. Farnesi, S. Berneschi, G. C. Righini, F. Quercioli, G. N. Conti, S. Soria. J. Lumin. 170, 860-865 (2016)
- Tomato fruit carotenoid biosynthesis is adjusted to actual ripening progression by a light-dependent mechanism Llorente, L. D’Andrea, M. Aguila Ruiz-Sola, E. Botterweg, P. Pulido, J. Andilla, P. Loza-Alvarez, M. Rodriguez-Concepcion. Plant J. 85, 107-119 (2016)
2015 & more
- Stochastic optical reconstruction microscopy (STORM) in comparison with stimulated emission depletion (STED) and other imaging methods Tam, D. Merino. J. Neurochem. 135, 643-658 (2015)
- Rapid spontaneous Raman light sheet microscopy using cw-lasers and tunable filters Rocha-Mendoza, J. Licea-Rodriguez, M. Marro, O. E. Olarte, M. Plata-Sanchez, P. Loza-Alvarez. Biomed. Opt. Express. 6, 3449-3461 (2015)
- Decoupled illumination detection in light sheet microscopy for fast volumetric imaging E. Olarte, J. Andilla, D. Artigas, P. Loza-Alvarez. Optica. 2, 702-705 (2015)
- Translational label-free nonlinear imaging biomarkers to classify the human corneal microstructure Lombardo, D. Merino, P. Loza-Alvarez, G. Lombardo. Biomed. Opt. Express. 6, 2803-2818 (2015)
- Fast monitoring of in-vivo conformational changes in myosin using single scan polarization-SHG microscopy Psilodimitrakopoulos, P. Loza-Alvarez, D. Artigas. Biomed. Opt. Express. 5, 4362-4373 (2014)
- Dynamic molecular monitoring of retina inflammation by in vivoRaman spectroscopy coupled with multivariate analysis Marro, A. Taubes, A. Abernathy, S. Balint, B. Moreno, B. Sanchez-Dalmau, E. H. Martínez-Lapiscina,
I. Amat-Roldan, D. Petrov, P. Villoslada. J. Biophoton. 7, 724-734 (2014) - Two-photon fluorescence imaging with 30 fs laser system tunable around 1 micron Resan, R. Aviles-Espinosa, S. Kurmulis, J. Licea-Rodriguez, F. Brunner, A. Rohrbacher, D. Artigas,
P. Loza-Alvarez, K. J. Weingarten. Opt. Express. 22, 16456-16461 (2014) - Molecular monitoring of epithelial-to-mesenchymal transition in breast cancer cells by means of Raman spectroscopy Marro, C. Nieva, R. Sanz-Pamplona, A. Sierra. Biochim. Biophys. Acta-Mol. Cell Res. 1843, 1785-1795 (2014)
- A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis Santana-Codina, R. Carretero, R. Sanz-Pamplona, T. Cabrera, E. Guney, B. Oliva, P. Clezardin, O. E. Olarte, P. Loza-Alvarez, A. Méndez-Lucas, J. C. Perales, A. Sierra. Mol. Cell. Proteomics. 12, 2111-2125 (2013)
- Quantitative imaging of microtubule alteration as an early marker of axonal degeneration after ischemia in neurons Psilodimitrakopoulos, V. Petegnief, N. de Vera, O. Hernandez, D. Artigas, A. M. Planas, P. Loza-Alvarez. Biophys. J. 104, 968-975 (2013)
- Femtosecond laser axotomy in Caenorhabditis elegansand collateral damage assessment using a combination of linear and nonlinear imaging techniques I. C. O. Santos, M. Mathew, O. E. Olarte, S. Psilodimitrakopoulos, P. Loza-Alvarez. PLoS ONE. 8, e58600 (2013)
- The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells Manzo, J. A. Torreno-Pina, B. Joosten, I. Reinieren-Beeren, E. J. Gualda, P. Loza-Alvarez, C. G. Figdor, M. F. Garcia-Parajo, A. Cambi. J. Biol. Chem. 287, 38946-38955 (2012)
- Effect of molecular organization on the image histograms of polarization SHG microscopy Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, D. Artigas. Biomed. Opt. Express 3, 2681-2693 (2012)
- High peak-power picosecond pulse generation at 1.26 µm using a quantum-dot-based external-cavity mode-locked laser and tapered optical amplifier Ding, R. Aviles-Espinosa, M. A. Cataluna, D. Nikitichev, M. Ruiz, M. Tran, Y. Robert, A. Kapsalis, H. Simos, C. Mesaritakis, T. Xu, P. Bardella, M. Rossetti, I. Krestnikov, D. Livshits, I. Montrosset, D. Syvridis, M. Krakowski, P. Loza-Alvarez, E. Rafailov. Opt. Express. 20, 14308-14320 (2012)
- Image formation by linear and nonlinear digital scanned light-sheet fluorescence microscopy with Gaussian and Bessel beam profiles E. Olarte, J. Licea-Rodriguez, J. A. Palero, E. J. Gualda, D. Artigas, J. Mayer, J. Swoger, J. Sharpe,
I. Rocha-Mendoza, R. Rangel-Rojo, P. Loza-Alvarez. Biomed. Opt. Express. 3, 1492-1505 (2012) - Molecular engineering of chromophores for combined second-harmonic and two-photon fluorescence in cellular imaging De Meulenaere, W. Q. Chen, S. Van Cleuvenbergen, M. L. Zheng, S. Psilodimitrakopoulos, R. Paesen, J. M. Taymans, M. Ameloot, J. Vanderleyden, P. Loza-Alvarez, X. M. Duan, K. Clays. Chem. Sci. 3, 984-995 (2012)
- Measurement and correction of in vivosample aberrations employing a nonlinear guide-star in two-photon excited fluorescence microscopy Aviles-Espinosa, J. Andilla, R. Porcar-Guezenec, O. E. Olarte, M. Nieto, X. Levecq, D. Artigas, P. Loza-Alvarez. Biomed. Opt. Express. 2, 3135-3149 (2011)
- Ultrastructural analysis of myocardiocyte sarcomeric changes in relation with cardiac dysfunction in human fetuses with intrauterine growth restriction I. Iruretagoyena, I. Torre, I. Amat-Roldan, S. Psilodimitrakopoulos, F. Crispi, P. Garcia-Canadilla, A. Gonzalez-Tendero, A. Nadal, E. Eixarch, P. Loza-Alvarez, D. Artigas, E. GratacosAm. J. Obstet. Gynecol. 204, S34 (2011)
- Compact ultrafast semiconductor disk laser: targeting GFP based nonlinear applications in living organisms Aviles-Espinosa, G. Filippidis, C. Hamilton, G. Malcolm, K. J. Weingarten, T. Südmeyer, Y. Barbarin, U. Keller, S. I.C.O. Santos, D. Artigas, P. Loza-Alvarez. Biomed. Opt. Express 2, 739-747 (2011)Highlighted in Photonics.com
- Live-cell imaging/femtosecond lasers: ultrafast lasers + thg microscopy = flexible in-vivo cell research Aviles-Espinosa, P. Loza-Alvarez, A. Brodschelm, W. Kaenders. OptoIQ. 3, 1-3 (2010)
- Third-harmonic generation for the study of Caenorhabditis elegansembryogenesis Aviles-Espinosa, S. I. C. O. Santos, A. Brodschelm, W. G. Kaenders, C. Alonso-Ortega, D. Artigas, P. Loza-Alvarez. J. Biomed. Opt. 15, 046020 (2010)
- Fast image analysis in polarization SHG microscopy Amat-Roldan, S. Psilodimitrakopoulos, P. Loza-Alvarez, D. ArtigasOpt. Express. 18, 17209-17219 (2010)
- Estimating the helical pitch angle of amylopectin in starch using polarization second harmonic generation microscopy Psilodimitrakopoulos, I. Amat-Roldan, P. Loza-Alvarez, D. Artigas. J. Opt. 12, 084007 (2010)
- A simple scanless two-photon fluorescence microscope using selective plane illumination Palero, S. I.C.O. Santos, D. Artigas, P. Loza-Alvarez. Opt. Express. 18, 8491-8498 (2010) Highlighted in Virtual Journal for Biomedical Optics
- Signalling effect of NIR pulsed lasers on axonal growth Mathew, I. Amat-Roldan, R. Andrés, S. I. C. O. Santos, D. Artigas, E. Soriano, P. Loza-AlvarezJ. Neurosci. Meth. 186, 196-201 (2010) Link to J. Neurosci. Meth.
- Real time imaging of femtosecond laser induced nano-neurosurgery dynamics in C. elegans I. C. O. Santos, M. Mathew, P. Loza-Alvarez. Opt. Express. 18, 364-372 (2010)
- In vivo, pixel-resolution mapping of thick filaments’ orientation in nonfibrilar muscle using polarization-sensitive second harmonic generation microscopy Psilodimitrakopoulos, S. I. C. O. Santos, I. Amat-Roldan, A. K. N. Thayil, D. Artigas, P. Loza-Alvarez. J. Biomed. Opt. 14, 014001 (2009) Link to J. Biomed. Opt. Highlighted in Virtual Journal for Biomedical Physics Research
- Estimation of the effective orientation of the SHG source in cortical neurons Psilodimitrakopoulos, V. Petegnief, G. Soria, I. Amat-Roldan, D. Artigas, A. M. Planas, P. Loza-Alvarez. Opt. Express 17, 14418-14425 (2009)
- Multimodal optical workstation for simultaneous linear, nonlinear microscopy and nanomanipulation: Upgrading a commercial confocal inverted microscope Mathew, S. I. C. O. Santos, D. Zalvidea, P. Loza-Alvarez. Rev. Sci. Instrum. 80, 073701 (2009)
- Myosin helical pitch angle as a quantitative imaging for characterization of cardiac programming in fetal growth restriction measured by Polarization Second Harmonic Microscopy Amat-Roldan, S. Psilodimitrakopoulos, E. Eixarch, I. Torre, B. Wotjas, F. Crispi, F. Figueras, D. Artigas, P. Loza-Alvarez, E. Gratacos. Proc. SPIE. 7367, 73670O (2009) Link to Proc. SPIE
- Quantitative discrimination between endogenous SHG sources in mammalian tissue, based on their polarization response Psilodimitrakopoulos, D. Artigas, G. Soria, I. Amat-Roldán, A. M. Planas, P.Loza-Álvarez. Opt. Express. 17, 10168-10176 (2009)
- Influence of distant femtosecond laser pulses on growth cone fillopodia Mathew, I. Amat-Roldán, R. Andrés, I. G. Cormark, D. Artigas, E. Soriano, P. Loza-Álvarez. Cytotechnology. 58, 103-111 (2008) Link to Cytotechnology
- Decrease in laser ablation threshold for epithelial tissue microsurgery in a living Drosophilaembryo during dorsal closure N. A. Thayil, A. Pereira, M. Mathew, D. Artigas, E. Martin-Blanco, P. Loza-Alvarez. J. Microsc. 232, 362-368 (2008) Link to J. Microsc.
- Nonlinear immunofluorescent assay for androgenic hormones based on resonant structures N. A. Thayil, A. Muriano, J.-P. Salvador, R. Galve, M. P. Marco, D. Zalvidea, P. Loza-Álvarez, T. Katchalski, E. Grinvald, A. A. Friesem, S. Soria. Opt. Express. 16, 13315-13322 (2008)
- Starch-based backwards SHG for in situMEFISTO pulse characterization in multiphoton microscopy N. A. Thayil, E. J. Gualda, S. Psilodimitrakopoulos, I. G. Cormack, I. Amat-Roldán, M. Mathew, D. Artigas, P. Loza-Álvarez. J. Microsc. 230, 70-75 (2008)
- Lost writing uncovered by laser two-photon fluorescence provides a terminus post quemfor Roman colonization of Hispania Citerior G. Cormack, P. Loza-Alvarez, L. Sarrado, S. Tomás, I. Amat, L. Torner, D. Artigas, J. Guitart, J. Pera, J. Ros. J. Archaeol. Sci. 34, 1594-1600 (2007) Link to J. Archaeol. Sci.
- Archaeophotonics: lasers unveil the past Artigas, I. G. Cormack, P. Loza-Alvarez. Opt. Photon. News 18(July/August), 20-25 (2007)
- Cavity resonances in finite plasmonic chains Ghenuche, I. G. Cormack, G. Badenes, P. Loza-Alvarez, R. Quidant. Appl. Phys. Lett. 90, 041109 (2007)
- Simultaneous analytical characterisation of two ultrashort laser pulses using spectrally resolved interferometric correlations Amat-Roldan, D. Artigas, I. G. Cormack, P Loza-Alvarez. Opt. Express. 14, 4538 – 4551 (2006)
- Optical Dyakonov surface waves at magnetic interfaces C. Crasovan, D. Artigas, D. Mihalache, L. Torner. Opt. Lett. 30, 3075-3077 (2005)
- Resonant double grating waveguide structures as enhancement platforms for two-photon fluorescence excitation Soria, A. Thayil, G. Badenes, M. A. Bader, A. Selle, G. Marowsky. Appl. Phys. Lett. 87, 081109 (2005)
- Mechanisms of refractive index modification during femtosecond laser writing of waveguides in alkaline lead-oxide silicate glass Vega, J. Armengol, V. Diez-Blanco, J. Siegel, J. Solis, B. Barcones, A. Pérez-Rodríguez, P. Loza-Alvarez. Appl. Phys. Lett. 87, 021109 (2005)
- Two-photon fluorescence sensors based on resonant grating waveguide structures Katchalski, S. Soria, E. Teitelbaum, A. A. Friesem, G. Morowsky. Sens. Actuators B-Chem. 107, 121-125 (2005)
- Measurement of electric field by interferometric spectral trace observation Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, D. Artigas. Opt. Lett. 30, 1063-1065 (2005)
- Starch-based second-harmonic-generated collinear frequency-resolved optical gating pulse characterization at the focal plane of a high-numerical-aperture lens Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, D. Artigas. Opt. Lett. 29, 2282-2284 (2004)
- Enhanced two-photon fluorescence excitation by resonant grating waveguide structures Soria, T. Katchalski, E. Teitelbaum, A. A. Friesem, G. Marowsky. Opt. Lett. 29, 1989-1991 (2004)
- Tunable and multiple-wavelengths/temporal output from gain-switched diode laser and a four Bragg-grating Fiber U. Rafailov, I. G. Cormack, F. Floreani, L. Zhang, I. Bennion, W. Sibbet. Appl. Phys. Lett. 85, 861-862 (2004)
- Periodically switched nonlinear structures for frequency conversion: theory and experimental demonstration Artigas, E. U. Rafailov, P. Loza-Alvarez, W. Sibbett. IEEE J. Quantum Electron. 40, 1122-1130 (2004)
- Ultrashort pulse characterisation with SHG collinear-FROG Amat-Roldan, I. G. Cormack, P. Loza-Alvarez, E. J. Gualda, D. Artigas. Opt. Express. 12, 1169-1178 (2004)
COLLABORATIONS
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